Scientific Publications on GCC

The following is a partial list of articles related to the GCC (GUCY2C) gene. We regularly update this list; it is recommended to visit on a regular basis. For more articles on the GCC gene, click here.

  1. Haince J-F., et al., Comparison of histopathology and RT-qPCR amplification of guanylyl cyclase C for detection of colon cancer metastases in lymph nodes, J Clin Pathol 2010; Volume 63, Issue 6:530-537

  2. Beaulieu M, et al., Analytical Performance of a qRT-PCR Assay to Detect Guanylyl Cyclase C in FFPE Lymph Nodes of Patients with Colon Cancer, Diag Mol Pathol. 2010 Mar;19(1):20-7

  3. Houde M, et al., Assessment of GCC expression as a prognostic marker of time to recurrence in colon cancer, 2010 ASCO Gastrointestinal Cancers Symposium, Orlando, FL, Abstract 293, poster presentation

  4. Beaulieu M, et al., Molecular Detection of Colorectal Cancer Lymph Node Occult Metastases, Association for Molecular Pathology 2008 Meeting Abstracts ST03, J. Mol. Diagn. 2008 10: 557-626

  5. Mejia A, et al, GUCY2C reverse transcriptase PCR to stage PNO colotectal cancer patients, Expert Review of Molecular Diagnostics, November 2009, Vol. 9, No. 8, Pages 777-785
  6. Mitchell E, Sargent D, Hamilton S. Molecular Markers and Prognosis of Patients with Colorectal Cancer, Independent Satellite Symposia, in conjunction to ASCO Gastrointestinal Cancers Symposium 2009
  7. Carlson MR. Previstage™ GCC Colorectal Cancer Staging Test, entreMeDica, Inc., Encinitas, California, USA, Mol Diag Ther 2009; 13(1):11-14
  8. E Lin J, Li P, Pitari GM , Schulz S, Waldman SA. Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target, Future Oncology, May 2009, Vol. 5, No. 4, Pages 509-522.
  9. Waldman SA, Hyslop T, Schulz S, Barkun A, Nielsen K, Haaf J, Bonaccorso C, Li Y, Weinberg DS. Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer. JAMA. 2009;301(7):745-752.
  10. Mejia A, Waldman S. Previstage™ GCC test for staging patients with colorectal cancer. Expert Reviews 2008; 8 (5): 571-578.
  11. Bilimoria KY, Bentrem DJ, Stewart AK, Talamonti MS, Winchester DP, Russell TR, Ko CY. Lymph Node Evaluation as a Colon Cancer Quality Measure: A National Hospital Report Card. J Natl Cancer Inst 2008 Sept 9; 352 (1): 1269
  12. Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR Jr, Hafer LJ. p66 Shc Tumor Levels Show a Strong Prognostic Correlation with Disease Outcome in Stage IIA Colon Cancer. Clin.Cancer Res., 13[19], 5798-5804. 2007
  13. Schulz S, Hyslop T, Haaf J, Bonaccorso C, Nielsen K, Witek ME, Birbe R, Palazzo J, Weinberg D, Waldman SA. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. Clin Cancer Res. 2006 Aug 1;12(15):4545-52
  14. Bustin A, Mueller R. Real-time reverse transcription PCR in the detection of occult disease in colorectal cancer, Mol Aspects Med. 2006 Apr-Jun;27(2-3):192-223.
  15. Frick GS, Pitari GM, Weinberg DS, Hyslop T, Schulz S, Waldman SA. Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer. Expert Rev Mol Diagn. 2005 Sep;5(5):701-13
  16. Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA. Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum Pathol. 2005 Feb;36(2):170-9
  17. Fava TA, Desnoyers R, Schulz S, Park J, Weinberg D, Mitchell E, Waldman SA. Ectopic expression of guanylyl cyclase C in CD34+ progenitor cells in peripheral blood. J Clin Oncol. 2001 Oct 1;19(19):3951-9
  18. Pitari GM, Di Guglielmo MD, Park J, Schulz S, Waldman SA. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc Natl Acad Sci U S A.2001 Jul 3;98(14):7846-51
  19. Gelmann A, Desnoyers R, Cagir B, Weinberg D, Boman BM, Waldman SA. Colorectal cancer staging and adjuvant chemotherapy. Expert Opinion on Pharmacother. 2000 May;1(4):737-55
  20. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev. 2000 Sep;52(3):375-414
  21. Cagir B, Gelmann A, Park J, Fava T, Tankelevitch A, Bittner EW, Weaver EJ, Palazzo JP, Weinberg D, Fry RD, Waldman SA. Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer. Ann Intern Med. 1999 Dec 7;131(11):805-12
  22. Carrithers SL, Barber MT, Biswas S, Parkinson SJ, Park PK, Goldstein SD, Waldman SA. Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14827-32